A central direction of the lab is long-read RNA-seq and DNA-seq analysis, with a focus on resolving complex transcript isoforms, structural variation, regulatory disruption, and multi-omics signals that are difficult to capture with short-read sequencing alone.

We also develop methods for Xenium spatial transcriptomics methodology development. We are especially interested in scalable cell segmentation, tissue architecture analysis, cell-state mapping, and cell-cell interaction modeling for immune-mediated disease research.

This blog will share lab updates, research notes, software releases, method explainers, and opportunities for students, postdocs, engineers, and clinicians.